Genetic impact of cannabis on in utero life and subsequent generational harms. Of major concern is the rising Community Cannabis Exposure (CCE) impacting exponential cannabinoid genotoxic dose-response relationships. CCE should be carefully restricted to protect the food chain, the genome, and the epigenome of coming generations 

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“Our research demonstrates that cannabis use in the general population is associated with heightened risk of clinically serious negative outcomes, specifically, needing to present to the ED [emergency department] or be admitted to hospital,” 

• Cannabis users were 22 percent more likely than those who don’t use to land in the emergency room or become hospitalized for any reason, suggesting use of the drug may be associated with negative health outcomes. 
• Bodily injury was the top reason for emergency department visits and hospitalizations among marijuana users, while respiratory issues came in second. 
• While recreational marijuana is still illegal in the U.S. under federal law, at least 19 states have passed legislation to allow sales of the drug.

(Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study | BMJ Open Respiratory Research)

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This paper has some of the Latest US study for 2022. (Executive Summary)

A difference-in-means test demonstrates that cannabis use is higher among all age groups in more highly permissive states, with 47 percent more monthly cannabis use among adolescents (ages 12-17) and 81 percent more monthly cannabis use among young adults (ages 18-25) in US states with fully legalized recreational cannabis programs than states where cannabis use has not been legalized. While cannabis use grew, subsequent raises in mean averages for major depressive events, severe mental illnesses, and suicidal thoughts all increased in more highly permissive US states. 

The research results presented in this study demonstrate that for each one percent increase in overall monthly cannabis use, self-reported major depression increased by 0.45 percent for adolescents and 0.21 percent for young adults. For every one percent increase in overall monthly cannabis use by young adults, severe mental illnesses increased by 0.12 percent and suicidal thoughts increased by 0.11 percent. Panel regression models included control variables for gender, marital status, educational attainment, veteran status, unemployment status, race, and ethnicity. 

On study of more than 8,500 cannabis products marketed online by more than 650 cannabis dispensaries in four western (CA, CO, NM, WA) and five northeastern (ME, MA, NH, RI, VT) states found the average medicinal cannabis product was advertised with a 19.2 percent THC  concentration and the average recreational cannabis product was advertised with a 21.5 percent THC concentration (Cash et al., 2020). A Dutch paper showed THC levels above 15 % THC is as dangerous as cocaine.

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Delta 8 THC Causing Cancer – Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study

From the Abstract Results indicate that between 8 and 20/34 cancer types were associated with Δ8THC exposure, with very high effect sizes (mEVs) and marginal effects after adjustment exceeding tobacco and alcohol, fulfilling the epidemiological criteria of causality and suggesting a cannabinoid class effect. The inclusion of pediatric leukemias and testicular cancer herein demonstrates heritable malignant teratogenesis. View Full-Text

Research published in https://www.mdpi.com/1660-4601/19/13/7726

Epidemiological association of cannabinoid- and drug- exposures and sociodemographic factors with limb reduction defects across USA 1989–2016: A geotemporospatial study

Introduction: Limb reductions (LR) are rare and dramatic defects which were first described several thousand years ago in the literature of antiquity (Bermejo-Sanchez et al., 2011b, 2011a). More recently they received prominence as the hallmark and initial indication of the teratogenic action of the drug thalidomide (Bermejo-Sanchez et al., 2011b, 2011a). LR includes both absence of proximal limb elements (intercalary segments, phocomelia) as well as complete limb absence (amelia)

Highlights

• Limb reduction rates (LRR) were associated with cannabis use, and THC potency.
• A sharp increase in LRR rates occurred from the fourth to the fifth quintile.
• These relationships were robust to adjustment for ethic and economic covariates.
• They were maintained at geospatiotemporal regression.
• Cannabis legalization was associated with higher LRR's.

Conclusion: Therefore, a spatiotemporal and dose-dependent association between several cannabinoids including THC and cannabigerol and LRR is reported, is robust to adjustment, is consistent with pathophysiological and preclinical studies, accords with findings elsewhere, is markedly exacerbated in higher exposure quintiles, is exacerbated by cannabis legalization and evidences dose-related intergenerational sequaelae.

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