A study from researchers at Indiana University has found that a major chemical component in marijuana called cannabidiol (CBD) appears to increase the pressure inside the eye. The results were reported in the journal Investigative Ophthalmology & Visual Science.
The study, which was conducted in mice, specifically found that CBD caused an increase in pressure inside the eye of 18% for at least 4 hours after use. Tetrahydrocannabinol, or THC, the primary psychoactive ingredient of marijuana, was found to effectively lower pressure in the eye, as has been previously reported. The Indiana University study found that the use of CBD in combination with THC blocked the effect of THC.
A new study took the same methodology of the previous study and expanded it to include states that legalized medical marijuana between 1999 and 2017 and found a surprising result: medical marijuana was associated with a 23% INCREASE in opioid deaths.
The Misplaced Optimism in Legal Pot Legalizing medical marijuana does not reduce the rate of fatal opioid overdoses, according to researchers at the Stanford University School of Medicine.
(National Academy of Science https://www.pnas.org/content/early/2019/06/04/1903434116)
Chelsea L. Shover, Corey S. Davis, Sanford C. Gordon, and Keith Humphreys Edited by Kenneth W. Wachter, University of California, Berkeley, CA, and approved May 16, 2019 (received for review February 27, 2019)
Medical cannabis has been touted as a solution to the US opioid overdose crisis since Bachhuber et al. [M. A. Bachhuber, B. Saloner, C. O. Cunningham, C. L. Barry, JAMA Intern. Med. 174, 1668–1673] found that from 1999 to 2010 states with medical cannabis laws experienced slower increases in opioid analgesic overdose mortality. That research received substantial attention in the scientific literature and popular press and served as a talking point for the cannabis industry and its advocates, despite caveats from the authors and others to exercise caution when using ecological correlations to draw causal, individual-level conclusions.
In this study, we used the same methods to extend Bachhuber et al.’s analysis through 2017. Not only did findings from the original analysis not hold over the longer period, but the association between state medical cannabis laws and opioid overdose mortality reversed direction from −21% to +23% and remained positive after accounting for recreational cannabis laws.
We also uncovered no evidence that either broader (recreational) or more restrictive (low-tetrahydrocannabinol) cannabis laws were associated with changes in opioid overdose mortality. We find it unlikely that medical cannabis—used by about 2.5% of the US population—has exerted large conflicting effects on opioid overdose mortality. A more plausible interpretation is that this association is spurious. Moreover, if such relationships do exist, they cannot be rigorously discerned with aggregate data. Research into therapeutic potential of cannabis should continue, but the claim that enacting medical cannabis laws will reduce opioid overdose death should be met with skepticism.
(National Academy of Sciences – USA: PNAS first published June 10, 2019 https://doi.org/10.1073/pnas.1903434116)
Just to lay the foundation, I have been diagnosed with post-traumatic stress disorder (PTSD), anxiety and depression…on a recent trip to Las Vegas, where Pot has been legalized, I decided to try a very small amount of chocolate with what they said was about 20 milligrams of THC to see if it would help me with some pain I was having.
What followed was a nightmare. It took roughly two hours to kick in and by the time it did, we were poolside. I literally felt like I was in and out of consciousness, couldn’t see clearly, could barely walk, felt totally paranoid and was convinced I was going to die in the jacuzzi because I couldn’t move or articulate that I needed to get out. This feeling reminded me of extreme depersonalization, which I’ve experienced before with my PTSD, but even worse. I felt like this the better part of the day, and slept on and off almost the entire day. It was a horrible experience and one I never wish to repeat again.
For complete article
STONED BABIES AND UNDERACHIEVING ADULTS
By Dr. Drew Edwards
Physicians and medical professionals routinely warn women not to use marijuana while they are pregnant or nursing. Why? The best available scientific evidence has established that exposure to marijuana’s psychoactive constituent, THC, in utero causes neuroadaptive changes in their baby’s brain, especially in the regions where their cognitive capacity and emotional regulation is formed. As a result, the life trajectories for prenatally exposed children may be permanently altered. These facts, like so many others germane to marijuana’s toxic effects have been well established in the scientific literature for years—and largely ignored.