{"id":1399,"date":"2016-10-21T14:16:00","date_gmt":"2016-10-21T03:16:00","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/thc-intoxication-by-cannabidiol-enriched-cannabis-extract-in-two-children-with-refractory-epilepsy\/"},"modified":"2025-11-12T21:00:38","modified_gmt":"2025-11-12T10:00:38","slug":"thc-intoxication-by-cannabidiol-enriched-cannabis-extract-in-two-children-with-refractory-epilepsy","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/thc-intoxication-by-cannabidiol-enriched-cannabis-extract-in-two-children-with-refractory-epilepsy\/","title":{"rendered":"THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy:"},"content":{"rendered":"<p>&Delta;9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol<\/p>\n<p>Jos&eacute; A. S. Crippa<sup>1<\/sup>*, Ana C. S. Crippa<sup>2<\/sup>, Jaime E. C. Hallak<sup>1<\/sup>, Rocio Mart&iacute;n-Santos<sup>1<\/sup>,<sup>3<\/sup>and Antonio W. Zuardi<sup>1<\/sup><\/p>\n<ul>\n<li><sup>1<\/sup>Department of Neuroscience and Behavior, University of S&atilde;o Paulo, Ribeir&atilde;o Preto, Brazil<\/li>\n<li><sup>2<\/sup>Department of Clinical Medicine, Federal University of Paran&aacute;, Curitiba, Brazil<\/li>\n<li><sup>3<\/sup>Institute of Neuroscience, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute &ndash; Center for Biomedical Research in Mental Health Network and Department of Medicine &ndash; University of Barcelona, Barcelona, Spain<\/li>\n<\/ul>\n<p>Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by &Delta;9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no &Delta;9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines.<\/p>\n<p><a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2016.00359\/full\" target=\"_blank\" class=\"button\">For more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&Delta;9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol Jos&eacute; A. S. Crippa1*, Ana C. S. Crippa2, Jaime E. C. Hallak1, Rocio Mart&iacute;n-Santos1,3and Antonio W. Zuardi1 1Department of Neuroscience and Behavior, University of S&atilde;o Paulo, Ribeir&atilde;o Preto, Brazil 2Department of Clinical Medicine, Federal University of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[15],"tags":[77],"class_list":["post-1399","post","type-post","status-publish","format-standard","hentry","category-cannabis-as-medicine","tag-cannabis-as-medicine"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/1399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=1399"}],"version-history":[{"count":0,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/1399\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=1399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=1399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=1399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}