{"id":2094,"date":"2019-05-13T13:53:17","date_gmt":"2019-05-13T03:53:17","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/longitudinal-changes-of-amygdala-functional-connectivity-in-adolescents-prenatally-exposed-to-cocaine\/"},"modified":"2019-05-13T13:53:17","modified_gmt":"2019-05-13T03:53:17","slug":"longitudinal-changes-of-amygdala-functional-connectivity-in-adolescents-prenatally-exposed-to-cocaine","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/longitudinal-changes-of-amygdala-functional-connectivity-in-adolescents-prenatally-exposed-to-cocaine\/","title":{"rendered":"Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine"},"content":{"rendered":"<p><strong style=\"background-color: inherit; color: inherit; font-family: inherit; font-size: 1rem;\">Highlights<\/strong><\/p>\n<ul>\n<li>\u2022 Prenatal cocaine exposure (PCE) is associated with long-term arousal dysregulation.<\/li>\n<li>\u2022 PCEs and controls were scanned with rfMRI at the mean ages of 14.3 and 16.6 years.<\/li>\n<li>\u2022 Amygdala connectivity changed oppositely with age in the PCE and control groups.<\/li>\n<li>\u2022 Amygdala connectivity in rest predicted emotional interference in task state.<\/li>\n<li>\u2022 PCE may contribute to increased emotional arousal in adolescent development.<\/li>\n<\/ul>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Background:&nbsp;<\/strong>Prenatal cocaine exposure (PCE) is associated with arousal dysregulation, but interactions between exposure and age are rarely investigated directly with longitudinal study designs. Our previous study had examined task-elicited emotional arousal and noted persistently high amygdala activations in the development of adolescents with PCE. However, while externally imposed emotional arousal could be considered a \u201cstate\u201d effect depending on specific task stimuli, it is still unclear whether similar developmental alterations extend to intrinsic functional connectivity (FC), reflecting more of a \u201ctrait\u201d effect.<\/p>\n<p><strong>Conclusions:&nbsp;<\/strong>These results provided additional data directly characterizing developmental changes in the emotional network of adolescents with PCE, complementing and extending the notion of a PCE-associated long-term teratogenic effect on arousal regulation.<\/p>\n<p><a class=\"button\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0376871619301280\" target=\"_blank\" rel=\"noopener\">For complete Study<\/a>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highlights \u2022 Prenatal cocaine exposure (PCE) is associated with long-term arousal dysregulation. \u2022 PCEs and controls were scanned with rfMRI at the mean ages of 14.3 and 16.6 years. \u2022 Amygdala connectivity changed oppositely with age in the PCE and control groups. \u2022 Amygdala connectivity in rest predicted emotional interference in task state. \u2022 PCE [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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