{"id":2601,"date":"2020-08-28T16:39:23","date_gmt":"2020-08-28T06:39:23","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/oral-thc-cbd-cannabis-extract-for-refractory-chemotherapy-induced-nausea-and-vomiting\/"},"modified":"2025-11-12T21:00:32","modified_gmt":"2025-11-12T10:00:32","slug":"oral-thc-cbd-cannabis-extract-for-refractory-chemotherapy-induced-nausea-and-vomiting","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/oral-thc-cbd-cannabis-extract-for-refractory-chemotherapy-induced-nausea-and-vomiting\/","title":{"rendered":"Oral THC:CBD Cannabis Extract for Refractory Chemotherapy-Induced Nausea and Vomiting"},"content":{"rendered":"<p><strong>Annals of Oncology<\/strong><\/p>\n<ul>\n<li data-mce-word-list=\"1\">In this phase II double-blind crossover study, patients with refractory chemotherapy-induced nausea and vomiting following intravenous chemotherapy receiving standard antiemesis prophylaxis were randomized to receive an oral THC: cannabidiol (CBD) combination pill or placebo. Multiple cancer types were included, and breast cancer accounted for about a third of cases. Complete response (no vomiting or use of rescue medications) was seen in 24% of patients while on THC:CBD versus 14% with placebo. There was no significant difference in reports of &#8220;no vomiting&#8221; with THC:CBD versus placebo.<\/li>\n<\/ul>\n<ul>\n<li data-mce-word-list=\"1\">While these results imply that THC:CBD in addition to standard antiemetic regimens may be associated with less nausea and vomiting, a larger phase III trial is ongoing to evaluate this association.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.practiceupdate.com\/c\/105256\/1\/1\/?elsca1=emc_enews_expert-insight&amp;elsca2=email&amp;elsca3=practiceupdate_onc&amp;elsca4=oncology&amp;elsca5=newsletter&amp;rid=MzM1MDQ1Nzg2NDU3S0&amp;lid=10332481\" target=\"_blank\" rel=\"noopener\" class=\"button\">For more<\/a>&nbsp;<\/p>\n<p>(also see <strong><a href=\"https:\/\/www.tga.gov.au\/publication\/guidance-use-medicinal-cannabis-prevention-or-management-nausea-and-vomiting-australia\" target=\"_blank\" rel=\"noopener\">Guidance for the use of medicinal cannabis for the prevention or management of nausea and vomiting in Australia \u2013 TGA<\/a>)<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Annals of Oncology In this phase II double-blind crossover study, patients with refractory chemotherapy-induced nausea and vomiting following intravenous chemotherapy receiving standard antiemesis prophylaxis were randomized to receive an oral THC: cannabidiol (CBD) combination pill or placebo. Multiple cancer types were included, and breast cancer accounted for about a third of cases. Complete response (no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[15],"tags":[77],"class_list":["post-2601","post","type-post","status-publish","format-standard","hentry","category-cannabis-as-medicine","tag-cannabis-as-medicine"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/2601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=2601"}],"version-history":[{"count":0,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/2601\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=2601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=2601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=2601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}