{"id":2978,"date":"2021-09-01T14:56:52","date_gmt":"2021-09-01T04:56:52","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/the-benefits-of-extended-release-naltrexone-paired-with-psychosocial-interventions-for-alcohol-use-disorder\/"},"modified":"2025-11-26T20:22:03","modified_gmt":"2025-11-26T09:22:03","slug":"the-benefits-of-extended-release-naltrexone-paired-with-psychosocial-interventions-for-alcohol-use-disorder","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/the-benefits-of-extended-release-naltrexone-paired-with-psychosocial-interventions-for-alcohol-use-disorder\/","title":{"rendered":"The Benefits of Extended-release Naltrexone Paired with Psychosocial Interventions for Alcohol Use Disorder"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2978\" class=\"elementor elementor-2978\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6eb08394 e-flex e-con-boxed e-con e-parent\" data-id=\"6eb08394\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11452787 elementor-widget elementor-widget-text-editor\" data-id=\"11452787\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Oral naltrexone has been shown to reduce alcohol consumption and craving in individuals with alcohol use disorder (AUD), yet evidence regarding the efficacy of the extended-release injectable formulation (XR-naltrexone) is limited. Researchers conducted a systematic review and meta-analysis of 7 randomized controlled trials evaluating 1500 adults with AUD receiving XR-naltrexone (150\u2013400 mg) for 2\u20136 months or placebo, plus some form of behavioral therapy. The primary outcome was the pooled weighted mean difference<\/p><p><em>Comments:\u00a0<\/em>With a modest reduction in drinking days and heavy drinking days per month compared with psychosocial interventions and placebo alone, the results of this meta-analysis suggest that XR-naltrexone may have some efficacy for AUD treatment, especially with longer treatment duration. Further research is needed to determine the long-term efficacy of XR-naltrexone, its effects among an actively drinking population, and how it compares (e.g., efficacy and cost) with oral naltrexone.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-506b59a elementor-widget elementor-widget-ucaddon_icon_pointer_button\" data-id=\"506b59a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_icon_pointer_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Icon Pointer Button -->\n\t\t<link id='font-awesome-css' href='https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' href='https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome6\/fontawesome-v4-shims.min.css' type='text\/css' rel='stylesheet' >\n\n<style>\/* widget: Icon Pointer Button *\/\n\n#uc_icon_pointer_button_elementor_506b59a *{\n\tmargin:0;\n\tbox-sizing: border-box;\n}\n\n#uc_icon_pointer_button_elementor_506b59a {\n  text-align:left;\n  direction: ltr;\n}\n\n#uc_icon_pointer_button_elementor_506b59a .icon_pointer_button_holder\n{\n  display:inline-block;\n}\n\n#uc_icon_pointer_button_elementor_506b59a a {\n\tdisplay: flex;\n\tposition: relative;\n\ttransition: all 0.3s;\n    text-decoration:none;\n    overflow:hidden;\n}\n\n#uc_icon_pointer_button_elementor_506b59a .icon_pointer_button_icon\n{\n  display:flex;\n  align-items:center;\n  justify-content:center;\n  position:relative;\n  transition: all 0.3s;\n}\n\n#uc_icon_pointer_button_elementor_506b59a .icon_pointer_button_text\n{\n  flex-grow: 1;\n  text-align:center;\n}\n\n\n\t\n#uc_icon_pointer_button_elementor_506b59a .icon_pointer_button_icon::after {\n\tcontent: \"\";\n    top: 50%;\n    clip-path: polygon(100% 50%, 0 0, 0 100%);\n  \ttransition: all 0.3s;\n  \tposition:absolute;\t\n      \tright: 0px;\t\n    transform: translateX(98%) translateY(-50%);\n  \t\t\n}  \n\n#uc_icon_pointer_button_elementor_506b59a .icon_pointer_button_icon_holder\n{\n  transition: all 0.3s;\n  display:block;\n  line-height:1em;\n  background-color:transparent;\n\n}\n\n<\/style>\n\n<div class=\"icon_pointer_button\" id=\"uc_icon_pointer_button_elementor_506b59a\">\n  \t<div class=\"icon_pointer_button_holder\">\n    <a href=\"https:\/\/www.bu.edu\/aodhealth\/2021\/08\/27\/the-benefits-of-extended-release-naltrexone-paired-with-psychosocial-interventions-for-alcohol-use-disorder\/\" class=\"ue-icon-btn\"  target='_blank'>\n       <span class=\"icon_pointer_button_icon\">\n         <span class=\"icon_pointer_button_icon_holder\"><i class=\"far fa-arrow-alt-circle-right\" aria-hidden=\"true\"><\/i><\/span>\n       <\/span>\n       <span class=\"icon_pointer_button_space\"><\/span>\n       <span class=\"icon_pointer_button_text\">For Complete Research<\/span>          \n    <\/a>\n    <\/div>\n<\/div>\n<!-- end Icon Pointer Button -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Oral naltrexone has been shown to reduce alcohol consumption and craving in individuals with alcohol use disorder (AUD), yet evidence regarding the efficacy of the extended-release injectable formulation (XR-naltrexone) is limited. Researchers conducted a systematic review and meta-analysis of 7 randomized controlled trials evaluating 1500 adults with AUD receiving XR-naltrexone (150\u2013400 mg) for 2\u20136 months [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[23],"tags":[],"class_list":["post-2978","post","type-post","status-publish","format-standard","hentry","category-naltrexone"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/2978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=2978"}],"version-history":[{"count":1,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/2978\/revisions"}],"predecessor-version":[{"id":9934,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/2978\/revisions\/9934"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=2978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=2978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=2978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}