{"id":3453,"date":"2023-01-11T13:25:02","date_gmt":"2023-01-11T02:25:02","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/long-term-outcomes-of-adolescent-thc-exposure-on-translational-cognitive-measures-in-adulthood-in-an-animal-model-and-computational-assessment-of-human-data\/"},"modified":"2025-11-12T21:02:03","modified_gmt":"2025-11-12T10:02:03","slug":"long-term-outcomes-of-adolescent-thc-exposure-on-translational-cognitive-measures-in-adulthood-in-an-animal-model-and-computational-assessment-of-human-data","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/long-term-outcomes-of-adolescent-thc-exposure-on-translational-cognitive-measures-in-adulthood-in-an-animal-model-and-computational-assessment-of-human-data\/","title":{"rendered":"Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data"},"content":{"rendered":"

JAMA Psychiatry. <\/i>Published online November 23, 2022.  doi:10.1001\/jamapsychiatry.2022.3915
Question<\/b>  Is there an association between adolescent high-dose \u00c49-tetrahydrocannabinol (THC) exposure and cognitive vulnerability in adulthood?
Findings<\/b>  In this rat model, high-dose THC exposure during adolescence resulted in risky decision-making and impulsivity in adulthood, similar to results from reanalyzed data from 37 human chronic cannabis users, an association enhanced by acute THC reexposure. Adolescent THC exposure induced cell-specific and layer-specific changes in cannabinoid-1 receptor gene expression and astrocyte perturbations in the amygdala and prelimbic cortex.
Meaning<\/b>  These results emphasize significant neurobiological outcomes of high-dose adolescent THC exposure and cognitive vulnerability in adulthood.
Abstract<\/b>
Importance<\/b>  Although perceived as relatively harmless and nonaddictive, adolescent cannabis use significantly increases the likelihood of developing cannabis use disorder in adulthood, especially for high-potency cannabis. Risky decision-making is associated with chronic cannabis use, but given confounds of human studies, it remains unclear whether adolescent cannabis exposure and \u00c49-tetrahydrocannabinol (THC) potency specifically predicts risky decision-making or influences cognitive response to the drug later in life.
Objective<\/b>  To leverage a human data set of cannabis users and a rat model to evaluate the long-term outcomes of adolescent THC exposure on adult decision-making and impulse control.
Conclusions and Relevance<\/b>  In this translational study, high-dose adolescent THC exposure was associated with cognitive vulnerability in adulthood, especially with THC re-exposure. These data also suggest a link between astrocytes and cognition that altogether provides important insights regarding the neurobiological genesis of risky cannabis use that may help promote prevention and treatment efforts.
(Source: JAMA Adolescent Psychiatry<\/a> )
<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

JAMA Psychiatry. Published online November 23, 2022.  doi:10.1001\/jamapsychiatry.2022.3915Question  Is there an association between adolescent high-dose \u00c49-tetrahydrocannabinol (THC) exposure and cognitive vulnerability in adulthood?Findings  In this rat model, high-dose THC exposure during adolescence resulted in risky decision-making and impulsivity in adulthood, similar to results from reanalyzed data from 37 human chronic cannabis users, an association enhanced by acute THC […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[16],"tags":[78],"class_list":["post-3453","post","type-post","status-publish","format-standard","hentry","category-cannabis-conundrum","tag-cannabis-conundrum"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/3453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=3453"}],"version-history":[{"count":0,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/3453\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=3453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=3453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=3453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}