{"id":3506,"date":"2023-02-15T17:26:05","date_gmt":"2023-02-15T06:26:05","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/study-shows-no-benefit-with-cbd-thc-for-peripheral-neuropathic-pain\/"},"modified":"2025-11-12T21:00:29","modified_gmt":"2025-11-12T10:00:29","slug":"study-shows-no-benefit-with-cbd-thc-for-peripheral-neuropathic-pain","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/study-shows-no-benefit-with-cbd-thc-for-peripheral-neuropathic-pain\/","title":{"rendered":"Study Shows No Benefit With CBD, THC for Peripheral Neuropathic Pain"},"content":{"rendered":"<p><span style=\"color: #333333;\"><a href=\"https:\/\/www.neurologyadvisor.com\/author\/jessica-nye\/\" target=\"_blank\" rel=\"noopener\"><b>Jessica Nye, PhD<\/b><\/a><b>&nbsp; February 8, 2023<\/b><br \/>Study authors did not identify clear pain-relieving effects from CBD and\/or THC among patients with peripheral neuropathic pain and prior treatment failure.<br \/>Oral cannabidiol (CBD), tetrahydrocannabinol (THC), or their combination did not decrease pain among patients with peripheral neuropathic pain who had a history of treatment failure. These findings, from a randomized, double-blind trial, were published in the&nbsp;<i>European Journal of Pain<\/i>.<br \/>The median age of the study population was 65 (range, 22-95) years, the median duration of pain was 60 (range, 10-2017) months, mean NRS score was 6.5 (standard deviation [SD], 1.3) points, and the most common prior therapy was gabapentin or pregabalin (n=115). Neuropathic etiologies included polyneuropathy (n=95), diabetic polyneuropathy<br \/><b><i>\u201cIn the PPP, CBD reduced pain less than placebo, and less effect of CBD than of placebo was also seen with some secondary pain outcomes.\u201d<\/i><\/b><br \/><b>Neither CBD, THC, nor CBD\/THC were superior to placebo for symptoms of burning pain, pressing and squeezing, pain paroxysms, or evoked pain as evaluated using the Neuropathic Pain Symptom Inventory (NPSI).&nbsp; The study authors report that CBD was actually less effective than placebo in reducing evoked pain.<\/b><br \/>No effects on paracetamol consumption, quality of life, or psychomotor function were reported with active treatment.<br \/><b>In subgroup analyses, active treatment was not superior to placebo for pain, quality of life, mood, or pain-related sleep disturbance.<\/b><br \/><b>Nausea and diarrhea were reported more frequently among recipients of CBD\/THC compared with prior to treatment (11% vs 1% and 11% vs 3%, respectively).<\/b><br \/><\/span><\/p>\n<p><span style=\"color: #333333;\">&nbsp;<a href=\"https:\/\/www.neurologyadvisor.com\/topics\/neuropathy\/no-benefit-with-cannabidiol-tetrahydrocannabinol-for-peripheral-neuropathic-pain\/?utm_source=eloqua&amp;utm_medium=email&amp;utm_campaign=NWLTR_NEU_UPDT_RSS-myCME-8184_020923_GB&amp;hmEmail=Ax4IjWp6ca2aniDJ%2BfxczEiE784%2F72iIgqbP1HaB5lo%3D&amp;sha256email=f69356ebe8055c1741d9cfc936a8d58ba5f7967da44b26cf5d8570df4b91941b&amp;hmSubId&amp;NID&amp;elqTrack=True\" target=\"_blank\" rel=\"noopener\" class=\"button\">For complete research<\/a><br \/><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jessica Nye, PhD&nbsp; February 8, 2023Study authors did not identify clear pain-relieving effects from CBD and\/or THC among patients with peripheral neuropathic pain and prior treatment failure.Oral cannabidiol (CBD), tetrahydrocannabinol (THC), or their combination did not decrease pain among patients with peripheral neuropathic pain who had a history of treatment failure. These findings, from a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[15],"tags":[77],"class_list":["post-3506","post","type-post","status-publish","format-standard","hentry","category-cannabis-as-medicine","tag-cannabis-as-medicine"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/3506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=3506"}],"version-history":[{"count":0,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/3506\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=3506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=3506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=3506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}