{"id":4143,"date":"2024-08-28T10:37:54","date_gmt":"2024-08-28T00:37:54","guid":{"rendered":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/unveiling-genetic-links-between-adhd-and-cannabis-use-disorder\/"},"modified":"2025-11-12T21:01:57","modified_gmt":"2025-11-12T10:01:57","slug":"unveiling-genetic-links-between-adhd-and-cannabis-use-disorder","status":"publish","type":"post","link":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/unveiling-genetic-links-between-adhd-and-cannabis-use-disorder\/","title":{"rendered":"Unveiling Genetic Links Between ADHD and Cannabis Use Disorder"},"content":{"rendered":"

\"adhd2\"Cannabis use disorder (CUD) and cannabis use (CU) are significant conditions frequently co-occurring with attention-deficit hyperactivity disorder (ADHD). A recent genome-wide association study (GWAS) has shed light on the genetic overlap between ADHD and these cannabis-related conditions. This article delves into the study\u2019s findings, highlighting the genetic loci associated with these disorders and their implications for understanding the comorbidity of ADHD and CUD or CU.<\/p>\n

Genetic Overlap Between ADHD and Cannabis Use Disorders<\/strong>: The GWAS identified 36 genome-wide significant loci that are concordant for both ADHD and CUD, and ten loci for ADHD and CU. One of the key risk genes identified for ADHD-CUD is DRD2. The study found that ADHD-CUD risk genes exhibited high expression levels across various brain tissues and developmental stages, a pattern not observed in ADHD-CU genes.<\/p>\n

Genetic Correlations and Substance Use<\/strong>: ADHD-CUD and ADHD-CU demonstrated similar genetic correlations with substance use; however, they differed significantly when it came to substance-use disorders. This differentiation underscores the complexity of the genetic interplay between ADHD and cannabis-related disorders.<\/p>\n

Polygenic Scores (PGS) and Psychiatric Disorders<\/strong>: Individuals with ADHD-CUD showed increased polygenic scores for psychiatric disorders compared to those with ADHD alone. Moreover, they also exhibited a higher burden of rare deleterious variants. These findings suggest that the genetic underpinnings of ADHD-CUD may contribute to a broader spectrum of psychiatric comorbidities.<\/p>\n

Risk Stratification<\/strong>: The stratification of individuals with ADHD by their CUD PGS revealed stark differences in the risk of developing comorbid CUD. Those in the highest CUD-PGS bin faced an absolute risk of 22% for comorbid CUD, which is substantially higher than the 1.6% risk observed among control individuals without ADHD.<\/p>\n

Implications<\/strong>: These findings provide critical insights into the genetic factors contributing to the co-occurrence of ADHD and cannabis use disorders. Understanding these genetic overlaps can inform targeted interventions and personalised treatment strategies for individuals at high risk of developing these comorbid conditions.<\/p>\n

Source:<\/strong> Nature<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cannabis use disorder (CUD) and cannabis use (CU) are significant conditions frequently co-occurring with attention-deficit hyperactivity disorder (ADHD). A recent genome-wide association study (GWAS) has shed light on the genetic overlap between ADHD and these cannabis-related conditions. This article delves into the study\u2019s findings, highlighting the genetic loci associated with these disorders and their implications […]<\/p>\n","protected":false},"author":1,"featured_media":4142,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":"","_wp_rev_ctl_limit":""},"categories":[16],"tags":[78],"class_list":["post-4143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cannabis-conundrum","tag-cannabis-conundrum"],"_links":{"self":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/4143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/comments?post=4143"}],"version-history":[{"count":0,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/posts\/4143\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media\/4142"}],"wp:attachment":[{"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/media?parent=4143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/categories?post=4143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dalgarnoinstitute.org.au\/wp_site\/wp-json\/wp\/v2\/tags?post=4143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}