Conclusions and Relevance  Results suggest that cannabis use during adolescence is associated with altered neurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence…accelerated thinning in the right dorsomedial prefrontal cortex was associated with the transition to cannabis use as well as greater attentional impulsiveness. 

Association of Cannabis Use During Adolescence With Neurodevelopment | Adolescent Medicine | JAMA Psychiatry | JAMA Network