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Executive SummaryÄ9-tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis, induces persistent epigenetic modifications — DNA methylation changes, histone post-translational modifications, and altered non-coding RNA expression — that disrupt mesolimbic reward circuitry, impair neuroplasticity, and elevate...
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More than 20,000 marijuana related deaths appeared on US death certificates between 2000 and 2024. That is the finding of a new analysis of the CDC’s WONDER database. The figures count marijuana poisoning or a...
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Abstract: Cannabis as a Gateway Drug for Opioid Use DisorderEmerging evidence suggests that adolescent cannabis use may biologically and behaviourally increase vulnerability to later opioid use and the development of opioid use disorder (OUD). The...
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Rising rates of cannabis use worldwide have renewed scientific attention on a question long overshadowed by the tobacco debate: what does inhaling burnt cannabis actually do to the human airway? A newly published Canadian investigation,...
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The federal marijuana rescheduling hearing has closed after twelve days of testimony. The closing witnesses left behind a sobering record. Rather than building a case for marijuana as ordinary medicine, the cannabis rescheduling case exposed...
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A major global review has linked commercial cannabis legalisation to rising rates of addiction, psychiatric hospital admissions and cannabis use disorder. Researchers at the University of Bath led the study, published in The Lancet Psychiatry....
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PMID: 41801216 . DOI: 10.1001/jamainternmed.2025.8215 Abstract Importance: Cannabis use is common among those with mental health conditions, and many people report using cannabis to manage mental health symptoms. It is important for clinicians to understand the lack of...
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Every year, another cohort of teenagers reaches the age where cannabis becomes available to them: through a dealer, a friend, or increasingly, a legal dispensary. Most try it once or twice and move on. A...
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For many people, cannabis now sits in the same mental basket as a glass of wine or a herbal sleep aid: familiar, legal in some places, and often marketed as a “natural” way to unwind....
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Received April 16, 2026; Published online April 22, 2026 DOI: 10.1016/j.lungcan.2026.109421 External Link Highlights Individuals with cannabis use disorder had an increased risk of any lung and/or bronchus cancer in this cohort study. Increased risk for...
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New Yale study suggests key clinical, cognitive, and brain-based differences. Key points Modern high-potency cannabis may be changing the landscape of psychotic disorders. Cannabis psychosis may be more than a temporary drug-induced condition. Continued cannabis...
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Background. Cannabidiol (CBD) now dominates consumer health markets worldwide. Manufacturers market it predominantly on the basis of perceived safety. However, CBD carcinogenicity FDA evidence, generated during the pharmaceutical approval process for purified CBD (Epidiolex, GW...
