Cannabis Conundrum

Key points Activation of cannabinoid receptor 1 (CB1R) by endocannabinoids or synthetic ligands mediates acute haemodynamic effects and might contribute to pathology in cardiovascular disease; activation of cannabinoid receptor 2 (CB2R) exerts anti-inflammatory effects The psychoactive constituent of marijuana, Δ9‑tetrahydrocannabinol (THC), exerts its cardiovascular effects via CB1R activation; at low doses it might have beneficial

Children eating the grown-ups ‘medicinal marijuana’ Gummy Bears, being not only sedated but experiencing a disease that affects brain structure and/or function. Encephalopathy causes altered mental state and confusion – Welcome to THC – and its analogues – use! Sedation and Acute Encephalopathy in a Paediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies Abstract BACKGROUND Delta-8

DOI: 10.3390/ijerph16214149 Abstract: Evidence for an association between cannabis and psychosis has been documented in literature in many forms including experimental studies, epidemiological data, and case series. The association has implications for psychotic outcomes ranging from mild to severe and occurring over minutes to years. Due to the huge variety of exposures and outcome measures reported,

Author links open overlay panel. https://doi.org/10.1016/j.jnma.2022.03.004Get rights and content Highlights Many states and District of Columbia in the United States have legalized marijuana. One reason is to expect marijuana to help reduce opioid dependence and mortality. However, opioid deaths have increased more where marijuana was legalized. This correlation is highly statistically significant for all opioids and fentanyl subgroup. The

Abstract – Aims: This study was designed to assess links between lifetime levels of marijuana use and accelerated epigenetic aging. Design: Prospective longitudinal study, following participants annually from age 13 to age 30. Findings: Lifetime marijuana use predicted accelerated epigenetic aging, with effects remaining even after covarying cell counts, demographic factors and chronological age (β’s = 0.32 &

Cannabis Causing Cancer Part 1 – Epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: Part 1: Complete Research here https://rdcu.be/cKfKp Conclusion: Data suggest that cannabinoids including THC and cannabidiol are important community carcinogens exceeding the effects of tobacco or alcohol. Testicular, (prostatic) and ovarian tumours indicate mutagenic

(Published in Neurology) TAKE-HOME MESSAGE In this AHA Scientific Statement, numerous effects of marijuana on brain health are described. These include the effects of: 1) prenatal cannabinoid exposure as well as abnormal fetal neurotransmission in preclinical models and its impact on neuroanatomic areas associated with cognition and emotional regulation; 2) marijuana use on human cognition focusing on possible structural

Aims: This study was designed to assess links between lifetime levels of marijuana use and accelerated epigenetic aging. Design: Prospective longitudinal study, following participants annually from age 13 to age 30. Setting and participants: A community sample of 154 participants recruited from a small city in the Southeastern United States. Measurements: Participants completed annual assessments

Chronic health conditions, acute health events, and healthcare utilization among adults over age 50 in Hawai’i who use cannabis: A matched cohort study  A B S T R A C T Background: Research on cannabis-related health outcomes in diverse older adults is limited. The current study utilized a matched cohort study design to compare older

Mulling up Cannabis and psychosis – Lancet Warning on Cannabis and Psychosis. Psychiatrist Dr Matthew Large, Clinical Senior Lecturer in the School of Psychiatry at the University of New South Wales,   Also see   View PDF