Cannabis Conundrum

THC Inhibits Hedgehog-dependent Patterning During Pregnancy

(Maternal cannabis use is associated with suppression of immune gene networks in placenta and increased anxiety phenotypes in offspring) PNAS November 23,2021; https://doi.org/10.1073/pnas.2106115118 Significance: Cannabis use is becoming more prevalent, including during developmentally sensitive periods such as pregnancy. Here we find that maternal cannabis use is associated with increased cortisol, anxiety, aggression, and hyperactivity in young children.

By Karen Schmidt, American Heart Association News At a time of increasing legalization of marijuana, a growing number of people under 50 diagnosed with cannabis use disorder were later hospitalized for a heart attack, new research has found. The rising trend from 2007 to 2018 was most pronounced in three groups: ages 18 to 34,

JAMA Psychiatry. 2021;78(9):1013-1019. doi:10.1001/jamapsychiatry.2021.1471 Question:  Has the population-attributable risk fraction for cannabis use disorder in schizophrenia increased over time, as would be expected with increasing use and potency of cannabis? Findings: In this Danish nationwide, register-based cohort study, the population-attributable risk fraction for cannabis use disorder in schizophrenia increased from approximately 2% in the period to 1995 to

CONCLUSIONS AND RELEVANCE: Considerable growth was observed in the prevalence of CUD diagnoses among individuals hospitalized prenatally and in the prevalence of depression, anxiety, nausea, and other conditions in individuals with CUD at hospitalization. This study  highlights the need for more screening, prevention, and treatment, particularly in populations with co-occurring CUD and psychiatric disorders. Research

JAMA Netw Open. 2021;4(9):e2125063. doi:10.1001/jamanetworkopen.2021.25063 Question  Has the number of vomiting-related emergency department visits increased after recreational cannabis legalization in Colorado? Findings  In this cross-sectional study of 820 778 patients seeking care through Colorado emergency departments, cannabis legalization was associated with an increase in annual vomiting-related health care encounters. The highest increases were observed in counties without existing medical

Prevalence of Adolescent Cannabis Vaping: A Systematic Review and Meta-analysis of US and Canadian Studies. JAMA Pediatr. Published online October 25, 2021. doi:10.1001/jamapediatrics.2021.4102 Key Points Question:  What is the prevalence of adolescent cannabis vaping in the US and Canada? Findings:  This systematic review and meta-analysis reviewed 17 unique studies from the US and Canada, with a total of

This study examined high-risk health behaviors in marijuana-users among a diverse college population in Southern California, post legalization of marijuana for recreational use. Study design: A cross-sectional research design was employed utilizing existing data via the 2018 National College Health Assessment (NCHA) from a large Minority-Serving Institution (MSI) population [n = 1345 (Hispanic/Latino/a, n = 456; White, n = 353; Asian Pacific

The link between tobacco smoke and lung cancer is well-known. Studies show that marijuana smoke has many of the same harmful substances as tobacco, and often more of them. Among the hazards are: Benzo(a)pyrene Benz(a)anthracene Phenols Vinyl chlorides Nitrosamines Reactive oxygen species People also smoke marijuana in a different way than tobacco, possibly posing greater danger to the lungs: You