Cannabis Conundrum

In Patients with Psychosis, Cannabis Use Is Associated with Adverse Clinical Outcomes

The link between cannabis use and the development of psychosis is established. This systematic review and meta-analysis of 24 studies summarizes the evidence of the impact of cannabis use after the onset of psychosis (schizophrenia, schizoaffective, or bipolar if outcome was reported as number of psychotic episodes). Researchers compared the outcomes of those who continued

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Cannabis and tolerance: acute drug impairment as a function of cannabis use history

“Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo.” “Overall, the present study demonstrates that cannabis induced impairment does not depend on cannabis use history and indicates that tolerance to impairing effects of cannabis on neurocognitive function is generally absent in frequent users. These data confirm

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Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder.

Wilkinson ST1, Stefanovics E, Rosenheck RA. Abstract OBJECTIVE: An increasing number of states have approved posttraumatic stress disorder (PTSD) as a qualifying condition for medical marijuana, although little evidence exists evaluating the effect of marijuana use in PTSD. We examined the association between marijuana use and PTSD symptom severity in a longitudinal, observational study. METHOD:

Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder. Read More »

Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders.

Authors Kelley ME, Wan CR, Broussard B, Crisafio A, Cristofaro S, Johnson S, Reed TA, Amar P, Kaslow NJ, Walker EF, Compton MT. Abstract OBJECTIVES:Several studies suggest that adolescent marijuana use predicts earlier age at onset of schizophrenia, which is a crucial prognostic indicator. Yet, many investigations have not adequately established a clear temporal relationship

Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders. Read More »

Cannabinoid hyperemesis syndrome.

Parekh JD, Wozniak SE, Khan K, Dutta SK. Abstract The antiemetic properties of marijuana are well known, but there is increasing evidence of its paradoxical hyperemetic effects on the gastrointestinal tract and central nervous system, known as ‘cannabinoid hyperemesis syndrome’ (CHS). We report a case of CHS encountered in our outpatient clinic. We also completed

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Cannabis ‘kills 30,000 a year’

by JENNY HOPE, Daily Mail More than 30,000 cannabis smokers could die every year, doctors warn today. Medical experts blame the Home Secretary for creating confusion about the risks posed by the drug – leading young people wrongly to believe it is harmless. They claim David Blunkett’s decision to reclassify cannabis as a class C

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