Chronic Cannabis Use & Coronary Disease: Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use
Question: Is chronic cannabis use associated with endothelial dysfunction? YES! Findings: In this cross-sectional study of 55 participants, vascular endothelial function was impaired in both chronic marijuana smokers and tetrahydrocannabinol (THC)–edible users, whereas serum from marijuana smokers but not THC-edible users blunted nitric oxide production in cultured endothelial cells. Meanings: Endothelial dysfunction was observed in