Cannabis Conundrum

Overall, investigators observed 22 and 31 DNA methylation markers associated with recent and cumulative marijuana use, respectively, from the first samples and 132 and 16 methylation markers in the second batch of samples, according to the study. Many of the epigenetic changes were found in pathways previously linked to cellular proliferation, hormone signaling, infections and

(From) Abstract: Recent European data facilitate an epidemiological investigation of the controversial cannabis–cancer relationship. Of particular concern were prior findings associating high-dose cannabis use with reproductive problems and potential genetic impacts… Cannabis is a more important carcinogen than tobacco and alcohol and fulfills epidemiological qualitative and quantitative criteria for causality for 25/41 cancers. Reproductive and transgenerational

 (for 16-25 y.o. homelessness) linked to cannabis use disorder: Homelessness is associated with cannabis use disorder more than all other drugs combined (including alcohol), Massachusetts General Hospital found in youth aged 16-25 years old experiencing homelessness. Rates of single and co-occurring psychiatric disorders and specific SUDs (cannabis use disorder [CUD] and alcohol use disorder [AUD]) were

Adverse childhood experiences are ‘strong predictor’ for adolescent cannabis use. Young people who are exposed to adverse childhood experiences between the ages of 0 – 12 years, including parental drug misuse, are at highest risk for developing problematic adolescent cannabis use as teenagers, according to a new study. Adverse childhood experiences (‘ACEs’) considered included physical, emotional

Marijuana and the teenage brain. Cognitive Effects: Detrimental Academic Performance: Detrimental Amotivational Syndrome: Detrimental Dopamine Regulation: Detrimental Social Withdrawal: Detrimental Impact on Future Goals: Detrimental Takeaways The use of marijuana in adolescence can disrupt the normal development of the brain’s endocannabinoid system. Excessive marijuana use can disrupt dopamine balance in the brain, leading to a blunted reward response. Raising awareness

Development of cannabis use disorder in medical cannabis users: A 9-month follow-up of a randomized clinical trial testing effects of medical cannabis card ownership Background: Evidence for long-term effectiveness of commercial cannabis products used to treat medical symptoms is inconsistent, despite increasingly widespread use. Objective: To prospectively evaluate the effects of using cannabis on self-reported symptoms of

Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study Abstract: The use of Δ8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of Δ8THC.

Recreational cannabis legalization alters associations among cannabis use, perception of risk, and cannabis use disorder treatment for adolescents and young adults Abstract Objective: This research investigates whether associations among adolescent and young adult perception of risk of harm from cannabis use, prevalence of past-month cannabis use, and rate of CUD treatment admissions changed following recreational cannabis legalization in