Cannabis Conundrum

Cannabis use disorder and adverse cardiovascular outcomes: A population-based retrospective cohort analysis of adults from Alberta, Canada Aim: To measure the association between cannabis use disorder (CUD) and adverse cardiovascular disease (CVD) outcomes. Participants: We identified participants with CUD diagnosis codes and matched them to participants without CUD codes by gender, year of birth and time of

Cannabis-Involved Traffic Injury Emergency Department Visits After Cannabis Legalization and Commercialization JAMA Netw Open. 2023;6(9):e2331551. doi:10.1001/jamanetworkopen.2023.31551 Key Points Question  Have cannabis-involved traffic injury emergency department visits changed after cannabis legalization and the subsequent commercialization of the cannabis retail market (ie, store and product expansion) in Ontario, Canada? Findings  In this cross-sectional study capturing 426 cannabis-involved traffic injury emergency

(Summary:  the following demographics should completely ABSTAIN from cannabis use: People aged 0-28 years of age (children and adolescents – developing brain) Pregnant women People with mental illness or vulnerable to such Drivers/Driving (one could also assume, anyone operating a vehicle of any kind) Whilst there are only some minor benefits from some cannabis derivatives,

Subtle but pervasive changes can occur between uses. Understanding THC’s interaction with the brain’s important natural cannabinoid chemistry and physiology will now make sense of the impact that overly frequent cannabis use has on the brain and mental functioning. Because THC stimulates our brain’s natural cannabinoid receptors (CB1) far more strongly and longer than the

 Int. J. Mol. Sci. 2023, 24(6), 5220; https://doi.org/10.3390/ijms24065220 In recent years, Cannabis use/misuse for treating pregnancy-related symptoms and other chronic conditions has increased among pregnant women, favored by decriminalization and/or legalization of its recreational uses in addition to its easy accessibility. However, there is evidence that prenatal Cannabis exposure might have adverse consequences on pregnancy progression and a deleterious impact on proper

Overall, investigators observed 22 and 31 DNA methylation markers associated with recent and cumulative marijuana use, respectively, from the first samples and 132 and 16 methylation markers in the second batch of samples, according to the study. Many of the epigenetic changes were found in pathways previously linked to cellular proliferation, hormone signaling, infections and

(From) Abstract: Recent European data facilitate an epidemiological investigation of the controversial cannabis–cancer relationship. Of particular concern were prior findings associating high-dose cannabis use with reproductive problems and potential genetic impacts… Cannabis is a more important carcinogen than tobacco and alcohol and fulfills epidemiological qualitative and quantitative criteria for causality for 25/41 cancers. Reproductive and transgenerational

 (for 16-25 y.o. homelessness) linked to cannabis use disorder: Homelessness is associated with cannabis use disorder more than all other drugs combined (including alcohol), Massachusetts General Hospital found in youth aged 16-25 years old experiencing homelessness. Rates of single and co-occurring psychiatric disorders and specific SUDs (cannabis use disorder [CUD] and alcohol use disorder [AUD]) were