Cannabis Conundrum

Adverse childhood experiences are ‘strong predictor’ for adolescent cannabis use. Young people who are exposed to adverse childhood experiences between the ages of 0 – 12 years, including parental drug misuse, are at highest risk for developing problematic adolescent cannabis use as teenagers, according to a new study. Adverse childhood experiences (‘ACEs’) considered included physical, emotional

Marijuana and the teenage brain. Cognitive Effects: Detrimental Academic Performance: Detrimental Amotivational Syndrome: Detrimental Dopamine Regulation: Detrimental Social Withdrawal: Detrimental Impact on Future Goals: Detrimental Takeaways The use of marijuana in adolescence can disrupt the normal development of the brain’s endocannabinoid system. Excessive marijuana use can disrupt dopamine balance in the brain, leading to a blunted reward response. Raising awareness

Development of cannabis use disorder in medical cannabis users: A 9-month follow-up of a randomized clinical trial testing effects of medical cannabis card ownership Background: Evidence for long-term effectiveness of commercial cannabis products used to treat medical symptoms is inconsistent, despite increasingly widespread use. Objective: To prospectively evaluate the effects of using cannabis on self-reported symptoms of

Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study Abstract: The use of Δ8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of Δ8THC.

Recreational cannabis legalization alters associations among cannabis use, perception of risk, and cannabis use disorder treatment for adolescents and young adults Abstract Objective: This research investigates whether associations among adolescent and young adult perception of risk of harm from cannabis use, prevalence of past-month cannabis use, and rate of CUD treatment admissions changed following recreational cannabis legalization in

While classical laboratory and animal data have long established cannabinoid genotoxicity, it is only recently, with the application of modern analytical techniques, that the scale of epidemiological disease that may be attributable to cannabinoid exposure has been revealed. The importance and urgency of this work is heightened by the increased cannabis use that is accompanying

A very limited study concluded that Smoking cannabis doesn’t carry the same COPD risk as tobacco ?? Ah, but for starters it didn’t include vaping, the now preferred insufflation delivery method for nicotine and any other substance. And it was limited to a small cohort. Vaping will carry an even higher risk than smoking.  We don’t

JAMA Psychiatry. Published online May 24, 2023.  Podcast Interview with Author Question:  Is cannabis use disorder associated with an increased risk of psychotic and nonpsychotic unipolar depression and bipolar disorder? Findings:  In this cohort study of 6 651 765 individuals in Demark, cannabis use disorder was associated with an increased risk of both psychotic and nonpsychotic unipolar depression and bipolar

Spain’s Universities of Leon and Oviedo found that “The gateway hypothesis holds that cannabis use increases other illegal substance use. Cannabis use duplicated the probabilities of tobacco and alcohol use.  Cannabis use increased 5 times the likelihood of use of other illegal drugs”. Testing the cannabis gateway hypothesis in a national sample of Spanish adolescents