Cannabis Conundrum

Abstract: The legalization of recreational and medical cannabis has increased the availability and potency of cannabis products in homes and communities. Although state laws regarding legalization and commercial sale often encompass adult use only, pediatric toxicity from unintentional exposures to cannabis edibles and adolescent harm from chronic use are increasing in states and countries that have

Prospective associations between cannabis use and depressive symptoms across adolescence and early adulthoodAbstract: Cannabis use and occurrences of depression during adolescence are common. However, the temporal relationship between the two is less understood. Does depression lead to cannabis use, or does cannabis use lead to depression, or is it a combination of both? Furthermore, this directionality

Cannabis & Motivation or Not or….Testing the Amotivational Syndrome: Marijuana Use Longitudinally Predicts Lower Self-Efficacy Even After Controlling for Demographics, Personality, and Alcohol and Cigarette Use Take away:  The research team found that only marijuana (but not alcohol or tobacco) intake significantly and longitudinally prompted lower initiative and persistence and provides partial support for the marijuana

Young men at highest risk of schizophrenia linked with cannabis use disorder May 4, 2023 NIH study highlights the need to proactively screen for, prevent, and treat cannabis use disorder especially among young people.Young men with cannabis (marijuana) use disorder have an increased risk of developing schizophrenia, according to a study led by researchers at the Mental

The Association Between Tobacco and Cannabis Use and the Age of Onset of Depression and Anxiety Symptoms Among Adolescents and Young AdultsAbstractPurpose: No studies have prospectively explored the association between the use of tobacco or cannabis use and the age of onset of depressive or anxiety symptoms, and no studies have identified the peak ages and

Summary: The prevalence of cannabis use in women of childbearing age is increasing drastically, likely related to increased legalization. Cannabis use during pregnancy is likely associated with preterm birth, low birth weight, and long-term neuropsychiatric outcomes, although data have significant limitations. Providers should screen for cannabis use and CUD regularly and counsel women about the known

AbstractBackground: The mechanisms underlying the clinical effects of CBD remain poorly understood. Given the increasing evidence for CBD’s effects on mitochondria, we sought to examine in more detail whether CBD impacts mitochondrial function and neuronal integrity. Results: At low micromolar concentrations, CBD reduced mitochondrial respiration, the threshold for mitochondrial permeability transition, and calcium uptake, blocked a novel

Potential birth defects, cancer and addiction – just name a few!Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog InteractionDOI: 10.1038/s41598-019-52336-w Abstract: We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signalling. The CBs, Ä9-THC, cannabidiol, HU-210, and CP 55,940 caused alcohol-like effects on craniofacial