Cannabis Conundrum

Long-term cannabis users showed statistically significant accelerated biological ageing and were less equipped to manage a range of later-life health, financial, and social demands than non-users. Standardised mean differences between long-term cannabis users and non-users were large: 0·70 (95% CI 0·46 to 0·94; p<0·0001) for biological ageing, –0·72 (–0·96 to –0·49, p<0·0001) for health preparedness,

New research suggests that smoking weed is far from benign: Toking every day might raise your odds of heart disease. The increased risk is not insignificant. Daily marijuana users are about one-third more likely to develop coronary artery disease, compared with people who have never used the drug, researchers say. For anyone with a heart

Cannabis & Driving – Research continues to Affirm the Risks & Dangers of THC (Cannabis) Use and Driving (Labelling it ‘Medicinal’ doesn’t reduce risks) The effects of cannabis and alcohol on driving performance and driver behaviour: a systematic  review and meta-analysisConclusions: This meta-analysis indicates that cannabis, like alcohol, impairs driving, andthe combination of the two drugs is

Summary: In conclusion, the present study describes the neurotoxicity of CBD above a defined concentration threshold and identifies a potential novel mechanism for this deleterious effect on the neuronal structure and function. Our results have significant implications for clinical utilization and public consumption of CBD and CBD containing products.Further investigations are necessary to firmly establish both the therapeutic

The (endo)cannabinoid signaling in female reproduction: What are the latest advances?Abstract: Cannabis extracts like marijuana have the highest consumption rate worldwide. Yet, their societal acceptance as recreational and therapeutic drugs could represent a serious hazard to female human reproduction, because cannabis ingredients [termed (phyto)cannabinoids] can perturb an endogenous system of lipid signals known as endocannabinoids.

Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms Abstract: Cannabis consumption during adolescence is an area of particular concern, owing to changes in the social and political perception of the drug, and presents a scientific, medical, and economic challenge. Major social and economic interests continue to push toward cannabis legalization as well as pharmaceutical development.

Abstract (Excerpt): As global interest in the therapeutic potential of cannabis and its’ derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern studies across a number of jurisdictions, including Canada,

Conclusion: This is the first characterization of the effect of cannabis exposure (CE)on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a “washout” period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental