Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data
JAMA Psychiatry. Published online November 23, 2022. doi:10.1001/jamapsychiatry.2022.3915Question Is there an association between adolescent high-dose Ä9-tetrahydrocannabinol (THC) exposure and cognitive vulnerability in adulthood?Findings In this rat model, high-dose THC exposure during adolescence resulted in risky decision-making and impulsivity in adulthood, similar to results from reanalyzed data from 37 human chronic cannabis users, an association enhanced by acute THC