Cannabis Conundrum

Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms Abstract: Cannabis consumption during adolescence is an area of particular concern, owing to changes in the social and political perception of the drug, and presents a scientific, medical, and economic challenge. Major social and economic interests continue to push toward cannabis legalization as well as pharmaceutical development.

Abstract (Excerpt): As global interest in the therapeutic potential of cannabis and its’ derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern studies across a number of jurisdictions, including Canada,

Conclusion: This is the first characterization of the effect of cannabis exposure (CE)on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a “washout” period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental

Geospatiotemporal and Causal Inferential Study of European Epidemiological Patterns of Cannabis- and Substance-Related Congenital Orofacial Anomalies Conclusion. Rising cannabis use is associated with all the Facial Congenital Abnormalities and fulfils the epidemiological criteria for causality. The data indicate particular concerns relating to brain development and exponential genotoxic dose-responses, urging caution with regard to community cannabinoid

NHS Scotland has dealt with 3,700 new patients in the last three years suffering from a range of psychotic delusions and hallucinations linked to the drug.For the first time, cannabinoids, the active compounds in the drug, are responsible for more fresh cases of psychiatric hospital admissions than any other drug. Experts say young people seem

Key Points Driving under the influence of cannabis has been identified as a public health concern as medical and recreational cannabis availability increases in some countries. A recent randomized clinical trial found similar levels of acute driving impairment with THC-dominant cannabis and with a combination of THC-CBD equivalent cannabis using on-road driving tests that provided

by Society for the Study of AddictionA systematic review published today in the scientific journal Addiction has found that cannabis use leads to acute cognitive impairments that may continue beyond the period of intoxication. This Canadian-led meta-review (review of reviews) merged the findings of 10 meta-analyses representing more than 43,000 participants.The study found that cannabis intoxication leads

Exposure to Pro and Anti-Cannabis Social Media Messages and Teens’ and College Students’ Intentions to Use Cannabis Content analyses have documented that posts about cannabis are increasingly common on social media. The relationship between the cannabis-related content to which teens and college students are exposed on social media and how such content may be associated

JAMA Health Forum. 2023;4(1):e225041. doi:10.1001/jamahealthforum.2022.5041Key PointsQuestion  What is the association between legalization of recreational cannabis edibles and unintentional pediatric cannabis poisoning?Findings  This cross-sectional study of all children (n = 3.4 million) aged 0 to 9 years across 4 Canadian provinces found that jurisdictions that allowed the sale of cannabis edibles experienced much larger increases in cannabis poisonings and proportions of