Cannabis Conundrum

Highlights: Less than a third of youth maintained a single mode of cannabis use across legalization. More than three times as many participants expanded their use modes as reduced them. Maintenance of multiple modes was associated with other substance use and depressive symptoms Using cannabis in multiple ways linked to binge drinking and depressive symptoms Conclusions: Multi-modal

The genotoxicity of Cannabis has long been suspected, even acknowledged, be it only in part. Research over the last 5 to 10 years has confirmed the case. Much of this important research has been ‘buried’ in the deluge of ‘hopeful’ and even spectacular claims of the potential therapeutic capacity of cannabis. Claims and promises that

Boredom, self-medication for increased depression and/or isolation, along with the various mental health issues that ramp up with a toxic combination of managing a legitimate mental health concern with a psychotropic toxin that only aids and abets mental health decline – not fix it. The vicious cycle of very short term ‘alleviation’ with self-medication, to

ABSTRACT Background and Aims The idea that cannabis is a ‘gateway drug’ to more harmful substances such as opioids is highly controversial, yet has substantially impacted policy, education and how we conceptualize substance use. Given a rise in access to cannabis products and opioid-related harm, the current study aimed to conduct the first systematic review

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July 11, 2021, BOULDER, Colo. — One day in fall 2018, Bo Gribbon began to vomit and couldn’t stop. He threw up multiple times an hour from morning to night before his mother drove him to the hospital near their home here. “It felt like Edwards Scissorhands was trying to grab my intestines and pull

Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely underpinning previous reports of links between cannabis and congenital anomalies and heritable tumours. However, the effects of cannabinoid genotoxicity have not been assessed on whole populations and formal consideration of effects as a broadly acting genotoxin

Published online: 17 Jun 2021 https://doi.org/10.1080/15563650.2021.1939881 Abstract Introduction On April 13, 2017, a bill to legalize cannabis was introduced to the Canadian Parliament and presented to the public. On October 17, 2018, Canada legalized recreational cannabis use. We assessed intoxication severity, reflected by ICU admission rates, risk factors and other characteristics in children who presented

JAMA Netw Open. 2021;4(6):e2113025. doi:10.1001/jamanetworkopen.2021.13025 Key Points Question  Are there associations between cannabis use and suicidality trends in young adults, and do they vary as a function of sex and depression? Findings  This survey study examined 281 650 adult participants in the 2008-2019 National Surveys of Drug Use and Health data and found associations of past-year cannabis use

Conclusions and Relevance  Results suggest that cannabis use during adolescence is associated with altered neurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence…accelerated thinning in the right dorsomedial prefrontal cortex was associated with the transition to cannabis use as well as greater attentional impulsiveness.