Cannabis as Medicine

Marijuana Is Not the Solution for PTSD — Evidence shows it does not treat PTSD in the long-term, and may worsen symptoms A growing number of states have identified post-traumatic stress disorder (PTSD) as an approved condition for medical marijuana. According to Colorado’s Medical Marijuana Registry, there are 70,533 patients as of February 2023 with an active

Potential birth defects, cancer and addiction – just name a few!Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog InteractionDOI: 10.1038/s41598-019-52336-w Abstract: We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signalling. The CBs, Ä9-THC, cannabidiol, HU-210, and CP 55,940 caused alcohol-like effects on craniofacial

Summary: In conclusion, the present study describes the neurotoxicity of CBD above a defined concentration threshold and identifies a potential novel mechanism for this deleterious effect on the neuronal structure and function. Our results have significant implications for clinical utilization and public consumption of CBD and CBD containing products.Further investigations are necessary to firmly establish both the therapeutic

The (endo)cannabinoid signaling in female reproduction: What are the latest advances?Abstract: Cannabis extracts like marijuana have the highest consumption rate worldwide. Yet, their societal acceptance as recreational and therapeutic drugs could represent a serious hazard to female human reproduction, because cannabis ingredients [termed (phyto)cannabinoids] can perturb an endogenous system of lipid signals known as endocannabinoids.

Abstract (Excerpt): As global interest in the therapeutic potential of cannabis and its’ derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern studies across a number of jurisdictions, including Canada,

Jessica Nye, PhD  February 8, 2023Study authors did not identify clear pain-relieving effects from CBD and/or THC among patients with peripheral neuropathic pain and prior treatment failure.Oral cannabidiol (CBD), tetrahydrocannabinol (THC), or their combination did not decrease pain among patients with peripheral neuropathic pain who had a history of treatment failure. These findings, from a

Conclusions: Accurate and informative labelling of hemp and hemp-derived CBD products is an important public health issue. FDA-regulated product labels are considered an essential tool for protecting consumers and enabling informed decision-making. Untruthful or unsubstantiated health-related claims, and unallowed Drug Claims, in marketing materials and on labels of CBD products may create harm by enticing consumers

Conclusion: This is the first characterization of the effect of cannabis exposure (CE)on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a “washout” period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental