Cannabis as Medicine

Summary: In conclusion, the present study describes the neurotoxicity of CBD above a defined concentration threshold and identifies a potential novel mechanism for this deleterious effect on the neuronal structure and function. Our results have significant implications for clinical utilization and public consumption of CBD and CBD containing products.Further investigations are necessary to firmly establish both the therapeutic […]

The (endo)cannabinoid signaling in female reproduction: What are the latest advances?Abstract: Cannabis extracts like marijuana have the highest consumption rate worldwide. Yet, their societal acceptance as recreational and therapeutic drugs could represent a serious hazard to female human reproduction, because cannabis ingredients [termed (phyto)cannabinoids] can perturb an endogenous system of lipid signals known as endocannabinoids.

Abstract (Excerpt): As global interest in the therapeutic potential of cannabis and its’ derivatives for the management of selected diseases increases, it is increasingly imperative that the toxic profile of cannabinoids be thoroughly understood in order to correctly assess the balance between the therapeutic risks and benefits. Modern studies across a number of jurisdictions, including Canada,

Jessica Nye, PhD  February 8, 2023Study authors did not identify clear pain-relieving effects from CBD and/or THC among patients with peripheral neuropathic pain and prior treatment failure.Oral cannabidiol (CBD), tetrahydrocannabinol (THC), or their combination did not decrease pain among patients with peripheral neuropathic pain who had a history of treatment failure. These findings, from a

Conclusions: Accurate and informative labelling of hemp and hemp-derived CBD products is an important public health issue. FDA-regulated product labels are considered an essential tool for protecting consumers and enabling informed decision-making. Untruthful or unsubstantiated health-related claims, and unallowed Drug Claims, in marketing materials and on labels of CBD products may create harm by enticing consumers

Conclusion: This is the first characterization of the effect of cannabis exposure (CE)on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a “washout” period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental

Abstract: There is an increase in the medical use of cannabis. However, the safety of medical cannabis, particularly for mental health conditions, has not yet been clearly established. Thus, this study assessed the risk of emergency department (ED) visits and hospitalization for depressive disorders among medical cannabis users. We conducted a retrospective longitudinal cohort study of

Researchers say despite the lack of symptom relief, more trials are needed to focus on the targeted use of medicinal cannabisMelissa Davey 29/11 2022The first high quality study looking at the impact of cannabidiol oil on palliative care patients with advanced cancer found it did not improve their pain, depression, anxiety, or quality of life.Palliative care

(Why not exploit the placebo effect of Cannabis, placebo’s will not addict!)There are numerous examples of the relationship between treatment expectations and placebo responses. If a person thinks they will experience relief from their pain by using a certain product or treatment, this can change the way they end up perceiving incoming pain signals – making them think