…The existing research clearly indicates several implications for alcohol policies, including guidelines: First, as most dose–response curves are monotonous, the lower the level of alcohol consumption overall, the better…it seems clear that less consumption is better (i.e., between 10 and 20 g/day [34,75]), and the risk is sex-specific.
This means that most current low-risk drinking guidelines have thresholds which are too high [75]. Second, as many of the dose–response curves are exponential, risk reduction is greater for heavier drinkers compared to moderate drinkers, if both reduce their drinking by the same number of drinks per day [18]. Empirical evidence suggests that this is best achieved by moving the overall population mean downwards [56,76].
