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The Benefits of Extended-release Naltrexone Paired with Psychosocial Interventions for Alcohol Use Disorder

Details
01 September 2021
404

Oral naltrexone has been shown to reduce alcohol consumption and craving in individuals with alcohol use disorder (AUD), yet evidence regarding the efficacy of the extended-release injectable formulation (XR-naltrexone) is limited. Researchers conducted a systematic review and meta-analysis of 7 randomized controlled trials evaluating 1500 adults with AUD receiving XR-naltrexone (150–400 mg) for 2–6 months or placebo, plus some form of behavioral therapy. The primary outcome was the pooled weighted mean difference

Comments: With a modest reduction in drinking days and heavy drinking days per month compared with psychosocial interventions and placebo alone, the results of this meta-analysis suggest that XR-naltrexone may have some efficacy for AUD treatment, especially with longer treatment duration. Further research is needed to determine the long-term efficacy of XR-naltrexone, its effects among an actively drinking population, and how it compares (e.g., efficacy and cost) with oral naltrexone.

For complete research

World Overdose Awareness Day 31 August 2021

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31 August 2021
247

#overdoseawareness #DemandReduction #preventdontpromote

worldoverdoseday

For More See Overdose Day - Does Nomenclature Matter?  and Naloxone  and Naltrexone

 

Is Bupropion Plus Naltrexone an Effective Treatment for Methamphetamine Use Disorder?  

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10 May 2021
375

Amphetamines are the second-most commonly used drug in the world and their use is rising in the US. There are currently no FDA-approved medications for treating methamphetamine use disorder (MUD). This multisite randomized controlled trial evaluated the efficacy and safety of extended-release naltrexone (380mg every 3 weeks) plus oral extended-release bupropion (450mg daily), compared with placebo for 6 weeks. The primary outcome was treatment response, defined as at least 3 out of 4 methamphetamine-negative urine drug tests over the last 2 weeks of the study.

  • The study enrolled 403 patients with moderate or severe MUD.
  • 15% of eligible patients were randomized; 69% of the participants were men.
  • Overall, 13.6% of patients in the intervention group had a treatment response, compared with 2.5% in the placebo group; this translates to a number needed to treat of 9.
  • The most common adverse effects were gastrointestinal disorders, tremor, malaise, hyperhidrosis, and anorexia.

Comments: Medications that are accessible and effective are urgently needed to treat MUD. Behavioral treatments like cognitive behavioral therapy and contingency management show favorable benefit, although their access remains very limited. This trial demonstrates a possible new treatment for MUD; however, limiting factors may be cost of the treatments and patient preference, both of which were not assessed.

For further Research

Combination therapy for methamphetamine use disorder (Naltrexone)

Details
10 February 2021
317

Researchers have begun testing drugs approved for other substance use disorders to treat people with methamphetamine addiction. Examples include naltrexone—which is used for the treatment of opioid use disorder—and bupropion, which helps people quit smoking.

Both treatments have shown some effectiveness when used alone to treat methamphetamine addiction. A research team led by Dr. Madhukar Trivedi at the University of Texas Southwestern Medical Center launched a clinical trial to see if a combination of the two might help more people quit.

For complete article

Bupropion and Naltrexone in Methamphetamine Use Disorder

Details
01 February 2021
402

New England Journal Medicine

Among adults with methamphetamine use disorder, the response over a period of 12 weeks among participants who received extended-release injectable naltrexone plus oral extended-release bupropion was low but was higher than that among participants who received placebo. (Funded by the National Institute on Drug Abuse and others; ADAPT-2 ClinicalTrials.gov number, NCT03078075..)

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About Us

The Dalgarno Institute was named after a woman who was a key figure in the early reformation movements of the mid 19th Century. Isabella Dalgarno personified the spirit of a large and growing movement of socially responsible people who had a heart for both social justice and social responsibility....

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