Recent research highlights that abstaining from cannabis for 28 days can lead to significant cognitive improvements and changes in brain activation among people with multiple sclerosis (MS). This study, presented by Omar Iqbal Khan, MD, emphasises the potential benefits of cannabis abstinence on the default mode network (DMN), which plays a crucial role in modulating cognition.
Key Findings
Cognitive Improvements: The cannabis withdrawal group exhibited significant improvements in multiple cognitive domains by the end of the 28-day period. These improvements underscore the potential cognitive benefits of abstaining from cannabis for individuals with MS.
Day 28 Differences:
- CW Group vs. CC Group: By day 28, the CW group showed increased activation in the left posterior cingulate and right angular gyrus (p < 0.05 for both, TFCE).
- Within CW Group: The CW group exhibited increased activation at day 28 versus baseline in the left posterior cingulate, right angular gyrus, left hippocampus (BA 36), and right medial prefrontal cortex (p < 0.05).
Implications for the Default Mode Network (DMN): The DMN is known to modulate cognition, and the study revealed enhanced DMN activity following cannabis abstinence. This finding provides objective evidence supporting the cognitive benefits of abstaining from cannabis for individuals with MS.
Summary: The study concluded that abstaining from cannabis for 28 days can reverse the activation of DMN activity and lead to improved cognition across several domains in people with MS. These findings offer valuable insights for counselling patients with MS and cognitive complaints about the potential benefits of cannabis abstinence.
Source: PracticeUpdate
