Cannabis in ALL FORMS takes a Weed Whacker to Your Chromosomes
with Professor, Dr. Stuart Reece

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While many Australians enjoy pleasures associated with drinking alcohol, we need to treat it with more caution, with alcohol consumption conservatively estimated to cost the Australian community $66.8 billion a year in health, workplace and other costs, according to research released today. This dollar figure covers some significant personal and community level harms.

Examining the Social and Economic Costs of Alcohol Use in Australia: 2017/18, published by the National Drug Research Institute (NDRI) at Curtin University in Perth, is the first national update in a decade of the costs of alcohol use. Using up-to-date methods of calculating costs and including a number of previously uncounted conditions and costs, it is substantially higher than the 2010 estimate of $14.4 billion. The main estimate includes some reference to ‘protective’ effects from alcohol, consistent with the evidence. A conservative estimate was made in our calculation of costs, as further harms where a reliable cost could not be estimated were excluded.

The research behind the updated national estimate was funded by the Australian Government Department of Health, and found that in the 2017-2018 financial year:

• alcohol was responsible for $18.2 billion in tangible costs including from: ill health; health service costs such as emergency department and hospital admissions; worker absence and occupational injuries; crime; road traffic crashes; and, alcohol purchases by those dependent on alcohol (but not by other alcohol consumers);
• alcohol was responsible for another $48.6 billion in intangible costs, which is the value of items that can’t be bought or sold, such as years of life lost from premature death, lost quality of life from living with alcohol dependence or from child abuse, and, impacts on victims of alcohol-caused crime; and,
• not included in the overall total were costs such as those associated with Fetal Alcohol Spectrum Disorder ($16 billion). There is a clear need for evidence about the prevalence of FASD to allow an accurate estimate of cost and to inform preventive and other responses.

There were several other critical areas where, due to limited data, reliable cost estimates were difficult to determine including: lost quality of life from living with someone with alcohol dependence; and, reduced workplace productivity (‘presenteeism’). Although not included in the overall total, indicative estimates suggested that these outcomes were highly likely to attract substantial costs.

“Alcohol continues to cause a significant toll through premature deaths, with 5,219 cases attributed to alcohol in 2017/18, personal suffering, reduced quality of life, and real financial costs in Australia,” Professor Allsop said.

“Nearly half-a-million Australians are dependent on alcohol, with many more drinking in a way that puts their health at risk. Importantly, any member of the community can be impacted by the drinking of others. The many adverse health effects and other consequences result in significant costs to society. Effective strategies to address alcohol related harms have the potential to substantially reduce medical costs, improve productivity, diminish crime, and lower costs to the whole community while improving community and individual wellbeing.”

 For more details

While many Australians enjoy pleasures associated with drinking alcohol, we need to treat it with more caution, with alcohol consumption conservatively estimated to cost the Australian community $66.8 billion a year in health, workplace and other costs, according to research released today. This dollar figure covers some significant personal and community level harms.

Examining the Social and Economic Costs of Alcohol Use in Australia: 2017/18, published by the National Drug Research Institute (NDRI) at Curtin University in Perth, is the first national update in a decade of the costs of alcohol use. Using up-to-date methods of calculating costs and including a number of previously uncounted conditions and costs, it is substantially higher than the 2010 estimate of $14.4 billion. The main estimate includes some reference to ‘protective’ effects from alcohol, consistent with the evidence. A conservative estimate was made in our calculation of costs, as further harms where a reliable cost could not be estimated were excluded.

The research behind the updated national estimate was funded by the Australian Government Department of Health, and found that in the 2017-2018 financial year:

• alcohol was responsible for $18.2 billion in tangible costs including from: ill health; health service costs such as emergency department and hospital admissions; worker absence and occupational injuries; crime; road traffic crashes; and, alcohol purchases by those dependent on alcohol (but not by other alcohol consumers);
• alcohol was responsible for another $48.6 billion in intangible costs, which is the value of items that can’t be bought or sold, such as years of life lost from premature death, lost quality of life from living with alcohol dependence or from child abuse, and, impacts on victims of alcohol-caused crime; and,
• not included in the overall total were costs such as those associated with Fetal Alcohol Spectrum Disorder ($16 billion). There is a clear need for evidence about the prevalence of FASD to allow an accurate estimate of cost and to inform preventive and other responses.

There were several other critical areas where, due to limited data, reliable cost estimates were difficult to determine including: lost quality of life from living with someone with alcohol dependence; and, reduced workplace productivity (‘presenteeism’). Although not included in the overall total, indicative estimates suggested that these outcomes were highly likely to attract substantial costs.

“Alcohol continues to cause a significant toll through premature deaths, with 5,219 cases attributed to alcohol in 2017/18, personal suffering, reduced quality of life, and real financial costs in Australia,” Professor Allsop said.

“Nearly half-a-million Australians are dependent on alcohol, with many more drinking in a way that puts their health at risk. Importantly, any member of the community can be impacted by the drinking of others. The many adverse health effects and other consequences result in significant costs to society. Effective strategies to address alcohol related harms have the potential to substantially reduce medical costs, improve productivity, diminish crime, and lower costs to the whole community while improving community and individual wellbeing.”

 For more details

THC Inhibits Hedgehog-dependent Patterning During Pregnancy

(Vaping linked to dysregulation of mitochondrial genes and immune response genes)

Nov 24 2021

Since they hit the market, e-cigarettes have been touted as a safe alternative to tobacco cigarettes for adult smokers. When research began to suggest otherwise, many questioned whether smoking was still to blame for adverse effects, since most vapers are either "dual users" who also smoke cigarettes or have a prior history of smoking.

Now, a team of researchers at the Keck School of Medicine of USC has demonstrated that - independent of the effects of prior smoking – using e-cigarettes is linked to adverse biological changes that can cause disease. The study, published in Scientific Reports, revealed that vapers experience a similar pattern of changes to gene regulation as smokers do, although the changes are more extensive in people who smoke.

Our study, for the first time, investigates the biological effects of vaping in adult e-cigarette users, while simultaneously accounting for their past smoking exposure. Our data indicate that vaping, much like smoking, is associated with dysregulation of mitochondrial genes and disruption of molecular pathways involved in immunity and the inflammatory response, which govern health versus disease state."

Ahmad Besaratinia, PhD, corresponding author and professor of research population and public health sciences at the Keck School of Medicine

"We found that more than 80% of gene dysregulation in vapers correlated with the intensity and duration of current vaping," said Besaratinia. "Whereas none of the detected gene dysregulation in vapers correlated to their prior smoking intensity or duration."

Effects of vaping mirror those of smoking

In previous research, Besaratinia and his team have shown that e-cigarette users develop some of the same cancer-related molecular changes in oral tissue as cigarette smokers. They also discovered vapers had the same kind of cancer-linked chemical changes to their genome as smokers.

In this study, they found that, in both vapers and smokers, mitochondrial genes are preferential targets of gene dysregulation. They also found that vapers and smokers had significant dysregulation of immune response genes.

Besaratinia says the findings are not only novel and significant, but they are also interrelated, since growing evidence shows that mitochondria play a critical role in immunity and inflammation.

"When mitochondria become dysfunctional, they release key molecules," said Besaratinia. "The released molecules can function as signals for the immune system, triggering an immune response that leads to inflammation, which is not only important for maintaining health but also plays a critical role in the development of various diseases, such as cardiovascular and respiratory diseases, metabolic diseases, and cancer."

"Given the popularity of e-cigarettes among young never-smokers, our findings will be of importance to the regulatory agencies," said Besaratinia. "To protect public health, these agencies are in urgent need of scientific evidence to inform the regulation of the manufacture, distribution, and marketing of e-cigarettes."

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